Summary: IRF5 polymorphisms are associated with multiple immune-mediated diseases, including ulcerative colitis.IRF5 contributions are attributed to its role in myeloid lineages.How T cell-intrinsic IRF5 contributes to inflammatory outcomes is not well understood.We identify a previously undefined key role for T cell-intrinsic IRF5.In mice, IRF5 in
Jawed vertebrates possess two distinct groups of muscles in the trunk (epaxial and hypaxial muscles) primarily defined by the pattern of motor innervation from the spinal cord.Of these, the hypaxial group includes muscles with highly ICE MAKER differentiated morphology and function, such as the muscles associated with paired limbs, shoulder girdles
Abstract Background RNA sequencing has become a ubiquitous technology used throughout life sciences as an effective method of measuring RNA abundance quantitatively in tissues and cells.The increase in use of RNA-seq technology has led to the continuous development of new tools for every step of analysis from alignment to downstream pathway analysi
Thrombosis is the predominant underlying mechanism of acute ischemic stroke (AIS).Though thrombolysis with tPA has Hay Bags been proven to be effective in treating AIS within the time window, the majority of AIS patients fail to receive tPA due to various reasons.Current medical therapies for AIS have limited efficacy and pose a risk of intracerebr